W 54011 | Tocris Bioscience 5455 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

W 54011

catalog :

5455

quantity :

10 mg (also 50 mg)

price :

287 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Sahu B, Rodriguez P, Nguyen M, Han R, Cero C, Razzoli M, et al. Peptide/Receptor Co-evolution Explains the Lipolytic Function of the Neuropeptide TLQP-21. Cell Rep. 2019;28:2567-2580.e6 pubmed publisher

product information

brand :

Tocris

master code :

5455

SKU :

5455/10

product name :

W 54011

description :

High affinity C5a receptor antagonist

target :

Complement Signaling inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

493.08

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

High affinity C5a receptor antagonist (Ki = 2.2 nM). Inhibits C5a-induced generation of reactive superoxide species, chemotaxis and intracellular Ca2+ mobilization in human neutrophils (IC50 values are 1.6, 2.7 and 3.1 nM, respectively).

catalog number base :

5455

product keywords :

W54011 high affinity C5a receptors antagonists antagonism neutrophils complement Complement 5455,

extended description :

High affinity C5a receptor antagonist

chemical name text :

N-[[4-(Dimethylamino)phenyl]methyl]-1,2,3,4-tetrahydro-7-methoxy-N-[4-(1-methylethyl)phenyl]-1-naphthalenecarboxamide hydrochloride

formula :

C 30 H 36 N 2 O 2 .HCl

formula text :

C30H36N2O2.HCl

cas num :

405098-33-1

2020 USD :

278

2021 USD :

287 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage