5455/10 | Tocris Bioscience 5455/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

5455/10

catalog :

5455/10

quantity :

10 mg (also 50 mg)

price :

360 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Pandey S, Kumari P, Baidya M, Kise R, Cao Y, Dwivedi Agnihotri H, et al. Intrinsic bias at non-canonical, β-arrestin-coupled seven transmembrane receptors. Mol Cell. 2021;81:4605-4621.e11 pubmed publisher
Sahu B, Rodriguez P, Nguyen M, Han R, Cero C, Razzoli M, et al. Peptide/Receptor Co-evolution Explains the Lipolytic Function of the Neuropeptide TLQP-21. Cell Rep. 2019;28:2567-2580.e6 pubmed publisher

image

image 1 :

Cat.No. 5455 - W 54011 C30H36N2O2.HCl CAS No. 405098-33-1

product information

master code :

5455

SKU :

5455/10

product name :

W 54011

unit size :

10 mg (also 50 mg)

description :

High affinity C5a receptor antagonist

target :

Complement Signaling inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

493.08

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

W 54011 is a high affinity C5a receptor antagonist (Ki = 2.2 nM). Inhibits C5a-induced generation of reactive superoxide species, chemotaxis and intracellular Ca2+ mobilization in human neutrophils (IC50 values are 1.6, 2.7 and 3.1 nM, respectively).

top caption :

High affinity C5a receptor antagonist

extended description :

High affinity C5a receptor antagonist

chemical name text :

N-[[4-(Dimethylamino)phenyl]methyl]-1,2,3,4-tetrahydro-7-methoxy-N-[4-(1-methylethyl)phenyl]-1-naphthalenecarboxamide hydrochloride

formula :

C30H36N2O2.HCl

formula text :

C30H36N2O2.HCl

cas num :

405098-33-1

USD :

360 USD

product details :

High affinity C5a receptor antagonist

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage