Erastin | Tocris Bioscience 5449 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Erastin

catalog :

5449

quantity :

10 mg

price :

221 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Bi J, Yang S, Li L, Dai Q, Borcherding N, Wagner B, et al. Metadherin enhances vulnerability of cancer cells to ferroptosis. Cell Death Dis. 2019;10:682 pubmed publisher
Wei Y, Tang T, Pang H. Cellular internalization of bystander nanomaterial induced by TAT-nanoparticles and regulated by extracellular cysteine. Nat Commun. 2019;10:3646 pubmed publisher

product information

brand :

Tocris

master code :

5449

SKU :

5449/10

product name :

Erastin

description :

Mitochondrial VDAC modulator; also Ferroptosis activator

target :

Ferroptosis Activators

category :

Small Molecules

unit size :

10 mg

purity :

98%

observed molecular weight :

547.04

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Antitumor agent; selective for cells expressing oncogenic RAS. Activates ferroptosis; induces oxidative, non-apoptotic cell death in tumors by modulating mitochondrial voltage-dependent anion channels (VDAC). Cell permeable.

catalog number base :

5449

product keywords :

Synthetic lethality antitumor agent RAS-selective lethal synthetic lethality KRAS, HRAS, BRAF small T ST oncoprotiens ferroptosis activators voltage-dependent anion channels VDAC Other Channel Modulators Ferroptosis 5449,

extended description :

Mitochondrial VDAC modulator; also Ferroptosis activator

chemical name text :

2-[1-[4-[2-(4-Chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-quinazolinone

formula :

C 30 H 31 ClN 4 O 4

formula text :

C30H31ClN4O4

cas num :

571203-78-6

2020 USD :

216

2021 USD :

221 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage