5449/10 | Tocris Bioscience 5449/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

5449/10

catalog :

5449/10

quantity :

10 mg

price :

292 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Ide S, Ide K, Abe K, Kobayashi Y, Kitai H, McKey J, et al. Sex differences in resilience to ferroptosis underlie sexual dimorphism in kidney injury and repair. Cell Rep. 2022;41:111610 pubmed publisher
Mukhopadhyay S, Goswami D, Adiseshaiah P, Burgan W, Yi M, Guerin T, et al. Undermining Glutaminolysis Bolsters Chemotherapy While NRF2 Promotes Chemoresistance in KRAS-Driven Pancreatic Cancers. Cancer Res. 2020;80:1630-1643 pubmed publisher
Bi J, Yang S, Li L, Dai Q, Borcherding N, Wagner B, et al. Metadherin enhances vulnerability of cancer cells to ferroptosis. Cell Death Dis. 2019;10:682 pubmed publisher
Wei Y, Tang T, Pang H. Cellular internalization of bystander nanomaterial induced by TAT-nanoparticles and regulated by extracellular cysteine. Nat Commun. 2019;10:3646 pubmed publisher

product information

master code :

5449

SKU :

5449/10

product name :

Erastin

unit size :

10 mg

description :

Mitochondrial VDAC modulator; also Ferroptosis activator

target :

Ferroptosis Activators

category :

Small Molecules

purity :

98%

observed molecular weight :

547.04

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Erastin is an antitumor agent; selective for cells expressing oncogenic RAS. Activates ferroptosis; induces oxidative, non-apoptotic cell death in tumors by modulating mitochondrial voltage-dependent anion channels (VDAC). Cell permeable.

top caption :

Mitochondrial VDAC modulator; also Ferroptosis activator

extended description :

Mitochondrial VDAC modulator; also Ferroptosis activator

chemical name text :

2-[1-[4-[2-(4-Chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-quinazolinone

formula :

C30H31ClN4O4

formula text :

C30H31ClN4O4

cas num :

571203-78-6

USD :

292 USD

product details :

Mitochondrial VDAC modulator; also Ferroptosis activator

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage