5443/10 | Tocris Bioscience 5443/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

5443/10

catalog :

5443/10

quantity :

10 mg (also 50 mg)

price :

297 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Berland C, Castel J, Terrasi R, Montalban E, Foppen E, Martin C, et al. Identification of an endocannabinoid gut-brain vagal mechanism controlling food reward and energy homeostasis. Mol Psychiatry. 2022;27:2340-2354 pubmed publisher
Cinar R, Gochuico B, Iyer M, Jourdan T, Yokoyama T, Park J, et al. Cannabinoid CB1 receptor overactivity contributes to the pathogenesis of idiopathic pulmonary fibrosis. JCI Insight. 2017;2: pubmed publisher

product information

master code :

5443

SKU :

5443/10

product name :

AM 6545

unit size :

10 mg (also 50 mg)

description :

High affinity and selective CB1 antagonist

target :

Cannabinoid R1/CB1 Antagonists

category :

Small Molecules

purity :

98%

observed molecular weight :

556.46

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

AM 6545 is a high affinity and selective CB1 antagonist (Ki = 3.3 nM). Exhibits 100-fold selectivity for CB1 over CB2 receptors. Improves glucose homeostasis, reverses hepatic steatosis and reduces body weight in diet-induced obese mice. Orally available and non-brain penetrant.

top caption :

High affinity and selective CB1 antagonist

extended description :

High affinity and selective CB1 antagonist

chemical name text :

5-[4-(4-Cyano-1-butyn-1-yl)phenyl]-1-(2,4-dichlorophenyl)-N-(1,1-dioxido-4-thiomorpholinyl)-4-methyl-1H-pyrazole-3-carboxamide

formula :

C26H23Cl2N5O3S

formula text :

C26H23Cl2N5O3S

cas num :

1245626-05-4

USD :

297 USD

product details :

High affinity and selective CB1 antagonist

storage :

Store at +4░C

more info or order :

Tocris Bioscience product webpage