5433/10 | Tocris Bioscience 5433/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

5433/10

catalog :

5433/10

quantity :

10 mg (also 50 mg)

price :

191 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Yang C, Lee Y, Hsu H, Zhao G, Lee S. Tyrphostin AG1024 Suppresses Coronaviral Replication by Downregulating JAK1 via an IR/IGF-1R Independent Proteolysis Mediated by Ndfip1/2_NEDD4-like E3 Ligase Itch. Pharmaceuticals (Basel). 2022;15: pubmed publisher
Martins Marques T, Ribeiro Rodrigues T, de Jager S, Zuzarte M, Ferreira C, Cruz P, et al. Myocardial infarction affects Cx43 content of extracellular vesicles secreted by cardiomyocytes. Life Sci Alliance. 2020;3: pubmed publisher
Yang C, Hsu H, Chang H, Lee Y, Lee S. Natural cardenolides suppress coronaviral replication by downregulating JAK1 via a Na+/K+-ATPase independent proteolysise. Biochem Pharmacol. 2020;180:114122 pubmed publisher
Qian H, Zhang N, Wu B, Wu S, You S, Zhang Y, et al. The E3 ubiquitin ligase Smurf2 regulates PARP1 stability to alleviate oxidative stress-induced injury in human umbilical vein endothelial cells. J Cell Mol Med. 2020;24:4600-4611 pubmed publisher

image

image 1 :

Cat.No. 5433 - Heclin C17H17NO3 CAS No. 890605-54-6

product information

master code :

5433

SKU :

5433/10

product name :

Heclin

unit size :

10 mg (also 50 mg)

description :

HECT E3 ubiquitin ligase inhibitor

target :

Ubiquitin Ligase (E3) Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

283.32

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Heclin is a HECT E3 ubiquitin ligase inhibitor; inhibits Nedd4, Smurf2 and WWP1 (IC50 values are 6.3, 6.8 and 6.9 M respectively). Selective for HECT-mediated over RING-mediated ubiquitination.

top caption :

HECT E3 ubiquitin ligase inhibitor

extended description :

HECT E3 ubiquitin ligase inhibitor

chemical name text :

N-(4-Acetylphenyl)-3-(5-ethyl-2-furanyl)-2-propenamide

formula :

C17H17NO3

formula text :

C17H17NO3

cas num :

890605-54-6

USD :

191 USD

product details :

HECT E3 ubiquitin ligase inhibitor

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage