product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
5431/10
catalog :
5431/10
quantity :
10 mg (also 50 mg)
price :
266 USD
more info or order :
citations: 4
Reference
Calbiague Garc xed a V, Cadiz B, Herrera P, D xed az A, Schmachtenberg O. Evaluation of Photobiomodulation and Boldine as Alternative Treatment Options in Two Diabetic Retinopathy Models. Int J Mol Sci. 2023;24: pubmed publisher
Padilla J, Lee B, Zhai K, Rentz B, Bobo T, Dowling N, et al. A Heme-Binding Transcription Factor BACH1 Regulates Lactate Catabolism Suggesting a Combined Therapy for Triple-Negative Breast Cancer. Cells. 2022;11: pubmed publisher
Maacha S, Hong J, von Lersner A, Zijlstra A, Belkhiri A. AXL Mediates Esophageal Adenocarcinoma Cell Invasion through Regulation of Extracellular Acidification and Lysosome Trafficking. Neoplasia. 2018;20:1008-1022 pubmed publisher
Liu L, MacKenzie K, Putluri N, Maletic Savatic M, Bellen H. The Glia-Neuron Lactate Shuttle and Elevated ROS Promote Lipid Synthesis in Neurons and Lipid Droplet Accumulation in Glia via APOE/D. Cell Metab. 2017;26:719-737.e6 pubmed publisher
product information
master code :
5431
SKU :
5431/10
product name :
SR 13800
unit size :
10 mg (also 50 mg)
description :
Potent MCT1 inhibitor
target :
Monocarboxylate Transporter Inhibitors
category :
Small Molecules
purity :
98%
observed molecular weight :
435.58
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
SR 13800 is a potent MCT1 inhibitor (IC50 = 0.5 nM); blocks proliferation of Raji lymphoma cells in vitro . Also inhibits lactate uptake in breast cancer cells in vitro .
top caption :
Potent MCT1 inhibitor
extended description :
Potent MCT1 inhibitor
chemical name text :
2,6-Dihydro-7-[(3-hydroxypropyl)thio]-2-methyl-4-(2-methylpropyl)-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyridazin-1one
formula :
C25H29N3O2S
formula text :
C25H29N3O2S
cas num :
227321-12-2
USD :
266 USD
product details :
Potent MCT1 inhibitor
storage :
Store at +4░C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK