5430/10 | Tocris Bioscience 5430/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

5430/10

catalog :

5430/10

quantity :

10 mg (also 50 mg)

price :

324 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Zhang D, Li L, Jiang H, Li Q, Wang Gillam A, Yu J, et al. Tumor-Stroma IL1β-IRAK4 Feedforward Circuitry Drives Tumor Fibrosis, Chemoresistance, and Poor Prognosis in Pancreatic Cancer. Cancer Res. 2018;78:1700-1712 pubmed publisher

image

image 1 :

Cat.No. 5430 - AS 2444697 C19H20N6O4.HCl CAS No. 1287665-60-4

product information

master code :

5430

SKU :

5430/10

product name :

AS 2444697

unit size :

10 mg (also 50 mg)

description :

Potent and selective IRAK4 inhibitor

target :

IRAK Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

432.86

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

AS 2444697 is a potent and selective interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor (IC50 = 21 nM). Displays 30-fold selectivity for IRAK4 over IRAK1. Inhibits LPS-induced TNF- and IL-6 production in PBMCs in vitro . Renoprotective and anti-inflammatory in a rodent model of chronic kidney disease.

top caption :

Potent and selective IRAK4 inhibitor

extended description :

Potent and selective IRAK4 inhibitor

chemical name text :

N-[3-Aminocarbonyl)-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl]-2-(2-methyl-4-pyridinyl)-4-oxazolecarboxamide hydrochloride

formula :

C19H20N6O4.HCl

formula text :

C19H20N6O4.HCl

cas num :

1287665-60-4

USD :

324 USD

product details :

Potent and selective IRAK4 inhibitor

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage