5424/10 | Tocris Bioscience 5424/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

5424/10

catalog :

5424/10

quantity :

10 mg

price :

284 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Hall A, Pohl S, Cammareri P, Aitken S, Younger N, Raponi M, et al. RNA splicing is a key mediator of tumour cell plasticity and a therapeutic vulnerability in colorectal cancer. Nat Commun. 2022;13:2791 pubmed publisher
Arendt K, Ntaliarda G, Armenis V, Kati D, Henning C, Giotopoulou G, et al. An In Vivo Inflammatory Loop Potentiates KRAS Blockade. Biomedicines. 2022;10: pubmed publisher

image

image 1 :

Cat.No. 5424 - Deltarasin C40H37N5O.3HCl CAS No. 1440898-82-7

product information

master code :

5424

SKU :

5424/10

product name :

Deltarasin

unit size :

10 mg

description :

High affinity PDE -KRas interaction inhibitor; binds to PDE

target :

Other Ras GTPase Compounds

category :

Small Molecules

purity :

99%

observed molecular weight :

713.14

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Deltarasin is a high affinity PDE -KRAS interaction inhibitor (Kd = 41 nM); binds to PDE . Reduces proliferation and induces cell death of KRAS-dependent Panc-Tu-1 and Capan-1 pancreatic cancer cells. Attenuates tumor growth of Panc-Tu-1 xenografts in mice.

top caption :

High affinity PDE -KRas interaction inhibitor; binds to PDE

extended description :

High affinity PDE -KRas interaction inhibitor; binds to PDE

chemical name text :

2-[4-[(2S)-2-(2-Phenyl-1H-benzimidazol-1-yl)-2-(4-piperidinyl)ethoxy]phenyl]-1-(phenylmethyl)-1H-benzimidazole trihydrochloride

formula :

C40H37N5O.3HCl

formula text :

C40H37N5O.3HCl

cas num :

1440898-82-7

USD :

284 USD

product details :

High affinity PDE -KRas interaction inhibitor; binds to PDE

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage