XL 184 | Tocris Bioscience 5422 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

XL 184

catalog :

5422

quantity :

10 mg (also 50 mg)

price :

221 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Martín Segura A, Casadomé Perales Á, Fazzari P, Mas J, Artigas L, Valls R, et al. Aging Increases Hippocampal DUSP2 by a Membrane Cholesterol Loss-Mediated RTK/p38MAPK Activation Mechanism. Front Neurol. 2019;10:675 pubmed publisher

product information

brand :

Tocris

master code :

5422

SKU :

5422/10

product name :

XL 184

description :

Potent VEGFR inhibitor; also inhibits other RTKs

target :

VEGF Receptor Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

501.51

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent VEGFR inhibitor (IC50 = 0.035 nM); also inhibits c-Met, KIT, RET, FLT4, AXL, FLT3, FLT1 and Tie2 (IC50 values are 1.3, 4.6, 5.2, 6, 7, 11.3, 12 and 14.3 nM, respectively). Induces intratumoral hypoxia and apoptosis. Reduces tumor invasion and metastasis in vivo . Antiangiogenic.

catalog number base :

5422

product keywords :

Potent VEGFR inhibitors inhibits HGFR HGF receptor vascular endothelial growth factors receptor, tyrosine kinases RTKs c-Met KIT FLT4 AXL FLT3 FLT1 Tie2 apoptosis metastasis antiangiogenics angiogenesis antitumor antitumour XL184 Cabozantinib BMS 907351 VEGFR FLT3 MET Receptors Other RTKs 5422, VEGFR, VEGF R

extended description :

Potent VEGFR inhibitor; also inhibits other RTKs

chemical name text :

N-[4-[(6,7-Dimethoxy-4-quinolinyl)oxy]phenyl]-N-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide

formula :

C 28 H 24 FN 3 O 5

formula text :

C28H24FN3O5

cas num :

849217-68-1

2020 USD :

214

2021 USD :

221 USD

alt names :

Cabozantinib, BMS 907351

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage