PCNA I1 | Tocris Bioscience 5419 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

PCNA I1

catalog :

5419

quantity :

10 mg (also 50 mg)

price :

138 USD

more info or order :

Tocris Bioscience product webpage

product information

brand :

Tocris

master code :

5419

SKU :

5419/10

product name :

PCNA I1

description :

PCNA inhibitor

target :

DNA, RNA and Protein Synthesis Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

310.37

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Proliferating cell nuclear antigen (PCNA) inhibitor. Directly binds PCNA trimers (Kd = 0.41 M), reduces chromatin-associated PCNA in cells, inhibits cell growth through induction of S and G2M arrest, and attenuates DNA replication in cells. Inhibits growth of a range of tumor cell lines in vitro with IC50 values in the nanomolar to low micromolar range. Inhibits growth of prostate tumor xenografts in mice.

catalog number base :

5419

product keywords :

PCNA11 Proliferating cell nuclear antigen PCNA inhibits inhibitors anticancer cell cycle arrest DNA, RNA and Protein Synthesis 5419,

extended description :

PCNA inhibitor

chemical name text :

N-(3-Methylthiophene-2-carboxylic acid)-N -[(1-hydroxy-2-naphthalenyl)methylene]hydrazide

formula :

C 17 H 14 N 2 O 2 S

formula text :

C17H14N2O2S

cas num :

444930-42-1

2020 USD :

135

2021 USD :

138 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage