WH-4-023 | Tocris Bioscience 5413 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

WH-4-023

catalog :

5413

quantity :

10 mg (also 50 mg)

price :

268 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Gao X, Nowak Imialek M, Chen X, Chen D, Herrmann D, Ruan D, et al. Establishment of porcine and human expanded potential stem cells. Nat Cell Biol. 2019;21:687-699 pubmed publisher
Shahbazi M, Scialdone A, Skorupska N, Weberling A, Recher G, Zhu M, et al. Pluripotent state transitions coordinate morphogenesis in mouse and human embryos. Nature. 2017;552:239-243 pubmed publisher

product information

brand :

Tocris

master code :

5413

SKU :

5413/10

product name :

WH-4-023

description :

Potent and selective Lck and Src inhibitor; also inhibits SIK

target :

Src Family Kinase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

568.67

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and selective Lck and Src inhibitor (IC50 values are 2 and 6 nM respectively). Exhibits 300-fold selectivity against p38 and KDR. Also potently inhibits SIK (IC50 values are 10, 22 and 60 nM for SIK 1, 2 and 3 respectively) and displays selectivity over a range of closely related kinases. Supports self-renewal of naive hESCs in combination with PD 0325901, CHIR 99021 and SB 590885 .

catalog number base :

5413

product keywords :

Potent selective Lck Src inhibitors inhibits self-renewal ESC lymphocyte specific kinase salt inducible kinase SIK KIN112 Src Kinases Other Kinases Stem Cell Proliferation 5413,

extended description :

Potent and selective Lck and Src inhibitor; also inhibits SIK

chemical name text :

2,6-Dimethylphenyl-N-(2,4-dimethoxyphenyl)-N-[2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]carbamate

formula :

C 32 H 36 N 6 O 4

formula text :

C32H36N6O4

cas num :

837422-57-8

2020 USD :

257

2021 USD :

268 USD

alt names :

KIN112

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage