5403/10 | Tocris Bioscience 5403/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

5403/10

catalog :

5403/10

quantity :

10 mg (also 50 mg)

price :

334 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Sarmah D, Meredith W, Weber I, Price M, Birtwistle M. Predicting anti-cancer drug combination responses with a temporal cell state network model. PLoS Comput Biol. 2023;19:e1011082 pubmed publisher

image

image 1 :

Cat.No. 5403 - TAK 960 hydrochloride C27H34F3N7O3.HCl CAS No. 2108449-45-0

product information

master code :

5403

SKU :

5403/10

product name :

TAK 960 hydrochloride

unit size :

10 mg (also 50 mg)

description :

Potent and selective PLK1 inhibitor

target :

Polo-like Kinase Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

598.06

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

TAK 960 hydrochloride is a potent PLK1 inhibitor (IC50 values are 0.8, 16.9 and 50.2 nM for PLK1, PLK2 and PLK3 respectively). Exhibits 20-fold selectivity for PLK1 over FAK, MLCK and FES, and has minimal activity against a panel of 282 other kinases. Inhibits proliferation of a range of cancer cell lines in vitro and inhibits tumor growth of multiple human cancer cell xenografts in vivo . Orally bioavailable.

top caption :

Potent and selective PLK1 inhibitor

extended description :

Potent and selective PLK1 inhibitor

chemical name text :

4-[(9-Cyclopentyl-7,7-difluoro-6,7,8,9-tetrahydro-5-methyl-6-oxo-5H-pyrimido[4,5-b][1,4]diazepin-2-yl)amino]-2-fluoro-5-methoxy-N-(1-methyl-4-piperidinyl)benzamide hydrochloride

formula :

C27H34F3N7O3.HCl

formula text :

C27H34F3N7O3.HCl

cas num :

2108449-45-0

USD :

334 USD

product details :

Potent and selective PLK1 inhibitor

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage