RQ 00203078 | Tocris Bioscience 5388 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

RQ 00203078

catalog :

5388

quantity :

10 mg (also 50 mg)

price :

208 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Gong K, Jasmin L. Sustained Morphine Administration Induces TRPM8-Dependent Cold Hyperalgesia. J Pain. 2017;18:212-221 pubmed publisher

product information

brand :

Tocris

master code :

5388

SKU :

5388/10

product name :

RQ 00203078

description :

Potent and selective TRPM8 antagonist; orally active

target :

TRPM Blockers

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

554.85

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent TRPM8 antagonist (IC50 values are 5.3 and 8.3 nM for rat and human channels respectively). Exhibits 350-fold selectivity for TRPM8 over TRPV4, TRPV1 and TRPA1. Reduces HSC3 and HSC4 oral squamous carcinoma cell migration and invasion in vitro . Also attenuates icilin -induced wet dog shakes in rats. Orally active.

catalog number base :

5388

product keywords :

RQ00203078 potent selective TRPM8 antagonists transient receptors potential channels orally active melastatin-related TRPM 5388,

extended description :

Potent and selective TRPM8 antagonist; orally active

chemical name text :

4-[[[3-Chloro-5-(trifluoromethyl)-2-pyridinyl][[4-(trifluoromethoxy)phenyl]methyl]amino]sulfonyl]benzoic acid

formula :

C 21 H 13 ClF 6 N 2 O 5 S

formula text :

C21H13ClF6N2O5S

cas num :

1254205-52-1

2020 USD :

203

2021 USD :

208 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage