5388/10 | Tocris Bioscience 5388/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

5388/10

catalog :

5388/10

quantity :

10 mg (also 50 mg)

price :

261 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Pratt S, Lee R, Chang K, Hern xe1 ndez Ochoa E, Annis D, Ory E, et al. Mechanoactivation of NOX2-generated ROS elicits persistent TRPM8 Ca2+ signals that are inhibited by oncogenic KRas. Proc Natl Acad Sci U S A. 2020;117:26008-26019 pubmed publisher
Gong K, Jasmin L. Sustained Morphine Administration Induces TRPM8-Dependent Cold Hyperalgesia. J Pain. 2017;18:212-221 pubmed publisher

image

image 1 :

Cat.No. 5388 - RQ 00203078 C21H13ClF6N2O5S CAS No. 1254205-52-1

product information

master code :

5388

SKU :

5388/10

product name :

RQ 00203078

unit size :

10 mg (also 50 mg)

description :

Potent and selective TRPM8 antagonist; orally active

target :

TRPM Blockers

category :

Small Molecules

purity :

98%

observed molecular weight :

554.85

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

RQ 00203078 is a potent TRPM8 antagonist (IC50 values are 5.3 and 8.3 nM for rat and human channels respectively). Exhibits 350-fold selectivity for TRPM8 over TRPV4, TRPV1 and TRPA1. Reduces HSC3 and HSC4 oral squamous carcinoma cell migration and invasion in vitro . Also attenuates icilin -induced wet dog shakes in rats. Orally active.

top caption :

Potent and selective TRPM8 antagonist; orally active

extended description :

Potent and selective TRPM8 antagonist; orally active

chemical name text :

4-[[[3-Chloro-5-(trifluoromethyl)-2-pyridinyl][[4-(trifluoromethoxy)phenyl]methyl]amino]sulfonyl]benzoic acid

formula :

C21H13ClF6N2O5S

formula text :

C21H13ClF6N2O5S

cas num :

1254205-52-1

USD :

261 USD

product details :

Potent and selective TRPM8 antagonist; orally active

storage :

Store at +4░C

more info or order :

Tocris Bioscience product webpage