C16 | Tocris Bioscience 5382 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

C16

catalog :

5382

quantity :

10 mg (also 50 mg)

price :

150 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Jiang Y, Steinle J. Epac1 inhibits PKR to reduce NLRP3 inflammasome proteins in retinal endothelial cells. J Inflamm Res. 2019;12:153-159 pubmed publisher

product information

brand :

Tocris

master code :

5382

SKU :

5382/10

product name :

C16

description :

PKR inhibitor

target :

Other Kinase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

268.29

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

PKR inhibitor (IC50 = 210 nM). Rescues PKR-dependent translation block in vitro . Decreases A 42-induced inflammatory cytokine release and apoptosis in neuronal cultures. Prevents neuroinflammation and neuronal loss in an acute excitotoxic rat model. Brain penetrant.

catalog number base :

5382

product keywords :

Double-stranded RNA-dependent proteins kinases PKR inhibitors inhibits neuroprotective neuroprotection neuroinflammation Other Kinases 5382,

extended description :

PKR inhibitor

chemical name text :

6,8-Dihydro-8-(1H-imidazol-5-ylmethylene)-7H-pyrrolo[2,3-g]benzothiazol-7-one

formula :

C 13 H 8 N 4 OS

formula text :

C13H8N4OS

cas num :

608512-97-6

2020 USD :

144

2021 USD :

150 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage