5382/10 | Tocris Bioscience 5382/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

5382/10

catalog :

5382/10

quantity :

10 mg (also 50 mg)

price :

190 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Zaman A, Wu X, Lemoff A, Yadavalli S, Lee J, Wang C, et al. Exocyst protein subnetworks integrate Hippo and mTOR signaling to promote virus detection and cancer. Cell Rep. 2021;36:109491 pubmed publisher
Demmings M, Tennyson E, Petroff G, Tarnowski Garner H, Cregan S. Activating transcription factor-4 promotes neuronal death induced by Parkinson's disease neurotoxins and α-synuclein aggregates. Cell Death Differ. 2020;: pubmed publisher
Jiang Y, Steinle J. Epac1 inhibits PKR to reduce NLRP3 inflammasome proteins in retinal endothelial cells. J Inflamm Res. 2019;12:153-159 pubmed publisher

product information

master code :

5382

SKU :

5382/10

product name :

C16

unit size :

10 mg (also 50 mg)

description :

PKR inhibitor

target :

Other Kinase Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

268.29

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

C16 is a PKR inhibitor (IC50 = 210 nM). Rescues PKR-dependent translation block in vitro . Decreases A 42-induced inflammatory cytokine release and apoptosis in neuronal cultures. Prevents neuroinflammation and neuronal loss in an acute excitotoxic rat model. Brain penetrant.

top caption :

PKR inhibitor

extended description :

PKR inhibitor

chemical name text :

6,8-Dihydro-8-(1H-imidazol-5-ylmethylene)-7H-pyrrolo[2,3-g]benzothiazol-7-one

formula :

C13H8N4OS

formula text :

C13H8N4OS

cas num :

608512-97-6

USD :

190 USD

product details :

PKR inhibitor

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage