Pregnenolone sulfate sodium salt | Tocris Bioscience 5376 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Pregnenolone sulfate sodium salt

catalog :

5376

quantity :

50 mg

price :

58 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Luoma J, Kelley B, Mermelstein P. Progesterone inhibition of voltage-gated calcium channels is a potential neuroprotective mechanism against excitotoxicity. Steroids. 2011;76:845-55 pubmed publisher

product information

brand :

Tocris

master code :

5376

SKU :

5376/50

product name :

Pregnenolone sulfate sodium salt

description :

NMDA potentiator; also GABAA inhibitor and TRPM3 activator

target :

Additional NMDA Receptor Compounds

category :

Small Molecules

unit size :

50 mg

observed molecular weight :

418.52

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Highly potent neurosteroid with multiple actions. Enhances intracellular Ca2+ upon NMDA receptor-mediated synaptic activity (EC50 ~ 2 pM) and potentiates NMDA responses. Inhibitor at GABAA receptors (IC50 values are 0.4 to 300 M, depending on specific subunit conformation). Activates CREB phosphorylation, augments LTP and cognitive behavior in rat memory models. Also activates TRPM3 channels.

catalog number base :

5376

product keywords :

neuroactive steroids highly potent NMDA TRPM3 memory LTP potentiators activates activators GABA NMDA Receptors TRPM GABAA Receptors 5376,

extended description :

NMDA potentiator; also GABAA inhibitor and TRPM3 activator

chemical name text :

(3 )-3-(Sulfooxy)-pregn-5-en-20-one sodium salt

formula :

C 21 H 31 NaO 5 S

formula text :

C21H31NaO5S

cas num :

1852-38-6

2020 USD :

2021 USD :

58 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage