5376/50 | Tocris Bioscience 5376/50 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

5376/50

catalog :

5376/50

quantity :

50 mg

price :

76 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Luoma J, Kelley B, Mermelstein P. Progesterone inhibition of voltage-gated calcium channels is a potential neuroprotective mechanism against excitotoxicity. Steroids. 2011;76:845-55 pubmed publisher

product information

master code :

5376

SKU :

5376/50

product name :

Pregnenolone sulfate sodium salt

unit size :

50 mg

description :

NMDA potentiator; also GABAA inhibitor and TRPM3 activator

target :

Additional NMDA Receptor Compounds

category :

Small Molecules

observed molecular weight :

418.52

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Pregnenolone sulfate sodium salt is a highly potent neurosteroid with multiple actions. Enhances intracellular Ca2+ upon NMDA receptor-mediated synaptic activity (EC50 ~ 2 pM) and potentiates NMDA responses. Inhibitor at GABAA receptors (IC50 values are 0.4 to 300 M, depending on specific subunit conformation). Activates CREB phosphorylation, augments LTP and cognitive behavior in rat memory models. Also activates TRPM3 channels.

top caption :

NMDA potentiator; also GABAA inhibitor and TRPM3 activator

extended description :

NMDA potentiator; also GABAA inhibitor and TRPM3 activator

chemical name text :

(3 )-3-(Sulfooxy)-pregn-5-en-20-one sodium salt

formula :

C21H31NaO5S

formula text :

C21H31NaO5S

cas num :

1852-38-6

USD :

76 USD

product details :

NMDA potentiator; also GABAA inhibitor and TRPM3 activator

storage :

Store at +4░C

more info or order :

Tocris Bioscience product webpage