C34 | Tocris Bioscience 5373 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

C34

catalog :

5373

quantity :

10 mg (also 50 mg)

price :

125 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Zhou J, Yang Y, Gan T, Li Y, Hu F, Hao N, et al. Lung cancer cells release high mobility group box 1 and promote the formation of neutrophil extracellular traps. Oncol Lett. 2019;18:181-188 pubmed publisher
Stephens M, Liao S, von der Weid P. Mesenteric Lymphatic Alterations Observed During DSS Induced Intestinal Inflammation Are Driven in a TLR4-PAMP/DAMP Discriminative Manner. Front Immunol. 2019;10:557 pubmed publisher
Zhang Z, La Placa D, Nguyen T, Kujawski M, Le K, Li L, et al. CEACAM1 regulates the IL-6 mediated fever response to LPS through the RP105 receptor in murine monocytes. BMC Immunol. 2019;20:7 pubmed publisher
Sun L, Li M, Ma X, Feng H, Song J, Lv C, et al. Inhibition of HMGB1 reduces rat spinal cord astrocytic swelling and AQP4 expression after oxygen-glucose deprivation and reoxygenation via TLR4 and NF-?B signaling in an IL-6-dependent manner. J Neuroinflammation. 2017;14:231 pubmed publisher

product information

brand :

Tocris

master code :

5373

SKU :

5373/10

product name :

C34

description :

TLR4 inhibitor

target :

Toll-like Receptor Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

observed molecular weight :

389.4

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

TLR4 inhibitor; attenuates TLR4 signaling in enterocytes and macrophages in vitro , and reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis (NEC). Also suppresses LPS signaling in human ileum displaying NEC ex-vivo . Displays no significant effects on signaling via TLR2 or TLR9.

catalog number base :

5373

product keywords :

TLR4 signaling mediated inflammatory diseases inhibitors inhibits endotoxemia necrotizing enterocolitis NEC TLR4-IN-C34 Toll-like Receptors 5373,

extended description :

TLR4 inhibitor

chemical name text :

1-Methylethyl 2-(acetylamino)-2-deoxy- -D-glucopyranoside 3,4,6-triacetate

formula :

C 17 H 27 NO 9

formula text :

C17H27NO9

cas num :

40592-88-9

2020 USD :

120

2021 USD :

125 USD

alt names :

TLR4-IN-C34

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage