chemical

TASP 0433864

5362

10 mg (also 50 mg)

180 USD

5362

5362/10

TASP 0433864

Selective positive allosteric modulator of mGlu2 receptors

Group II mGluR Modulators

Small Molecules

10 mg (also 50 mg)

98%

329.39

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Selective mGlu2 receptor positive allosteric modulator (EC50 values are 199 and 206 nM for human and rat receptors, respectively). Exhibits negligible activity against a range of neurotransmitter targets, except 5-HT2B and MAO-B (72 and 92% inhibition at 10 M, respectively). Potentiates inhibitory effect of DCG IV (Cat. No. 0975) on excitatory postsynaptic potentials in hippocampal slices and ketamine- and methamphetamine-induced increases in locomotor activity in rats and mice.

5362

TASP0433864 metabotropic glutamate receptors 2 positive allosteric modulators modulates mGlu2 mGluR selective PAM Glutamate (Metabotropic) Group II Receptors 5362,

Selective positive allosteric modulator of mGlu2 receptors

(2S)-2-[[4-(1,1-Dimethylethyl)phenoxy]methyl]-2,3-dihydro-5-methylimidazo[2,1-b]oxazole-6-carboxamide

C 18 H 23 N 3 O 3

C18H23N3O3

1431980-60-7

176

180 USD

Store at +4°C