5353/1 | Tocris Bioscience 5353/1 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

5353/1

catalog :

5353/1

quantity :

1 mg

price :

294 USD

more info or order :

Tocris Bioscience product webpage

citations: 6

Reference
Tauchi M, Oshita K, Urschel K, Furtmair R, K xfc hn C, Stumpfe F, et al. The Involvement of Cx43 in JNK1/2-Mediated Endothelial Mechanotransduction and Human Plaque Progression. Int J Mol Sci. 2023;24: pubmed publisher
Collado Diaz V, Martinez Cuesta M, Blanch Ruiz M, Sánchez Lopez A, García Martínez P, Peris J, et al. Abacavir Increases Purinergic P2X7 Receptor Activation by ATP: Does a Pro-inflammatory Synergism Underlie Its Cardiovascular Toxicity?. Front Pharmacol. 2021;12:613449 pubmed publisher
Ma J, Ji D, Li Q, Zhang T, Luo L. Inhibition of connexin 43 attenuates oxidative stress and apoptosis in human umbilical vein endothelial cells. BMC Pulm Med. 2020;20:19 pubmed publisher
Best S, Ding S, Kersbergen A, Dong X, Song J, Xie Y, et al. Distinct initiating events underpin the immune and metabolic heterogeneity of KRAS-mutant lung adenocarcinoma. Nat Commun. 2019;10:4190 pubmed publisher
Chen Y, Wang L, Zhang L, Chen B, Yang L, Li X, et al. Inhibition of Connexin 43 Hemichannels Alleviates Cerebral Ischemia/Reperfusion Injury via the TLR4 Signaling Pathway. Front Cell Neurosci. 2018;12:372 pubmed publisher
Almad A, Doreswamy A, Gross S, Richard J, Huo Y, Haughey N, et al. Connexin 43 in astrocytes contributes to motor neuron toxicity in amyotrophic lateral sclerosis. Glia. 2016;64:1154-69 pubmed publisher

product information

master code :

5353

SKU :

5353/1

product name :

Gap19

unit size :

1 mg

description :

Cx43 hemichannel blocker

target :

Gap Channel Blockers

category :

Peptides

purity :

95%

observed molecular weight :

1161.45

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=peptides

details of functionality :

Gap19 is a selective connexin 43 (Cx43) hemichannel blocker; has no effect on gap junction coupling or Panx-1 channels. Reduces mitochondrial potassium influx in cardiomyocytes and attenuates glutamate-triggered ATP release in primary astrocytes. Modestly reduces infarct size in a mouse ischemia model.

top caption :

Cx43 hemichannel blocker

extended description :

Cx43 hemichannel blocker

formula :

C55H96N14O13

formula text :

C55H96N14O13

cas num :

1507930-57-5

USD :

294 USD

product details :

Cx43 hemichannel blocker

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage