chemical

PQ 69

5351

10 mg (also 50 mg)

247 USD

5351

5351/10

PQ 69

Potent and selective A1 inverse agonist

Adenosine A1 Receptor Inverse Agonists

Small Molecules

10 mg (also 50 mg)

98%

350.39

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Potent and selective A1 receptor inverse agonist. Exhibits high binding affinity at A1 receptor (Ki values are 0.07 and 0.96 nM for rat and human receptors respectively). Reduces basal [35S]-GTP S binding 44.6% (IC50 = 0.19 nM). Antagonizes the effects of A1 agonist R-PIA (IC50 = 18.3 nM) and exhibits competitive antagonism on CCPA -induced tracheal contractions ex vivo . Displays 217- fold selectively over hA2A receptor and 1000-fold selectivity over hA3 receptor.

5351

PQ69 Potent selective A1 antagonists receptors adenosines inverse agonists Adenosine A1 Receptors 5351,

Potent and selective A1 inverse agonist

4-(Butylamino)-2-(3-fluorophenyl)-1,2-dihydro-3H-pyrazolo[4,3-c]quinolin-3-one

C 20 H 19 FN 4 O

C20H19FN4O

910045-32-8

247

247 USD

Store at +4°C