6,8-Bis(benzylthio)octanoic acid | Tocris Bioscience 5348 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

6,8-Bis(benzylthio)octanoic acid

catalog :

5348

quantity :

10 mg (also 50 mg)

price :

150 USD

more info or order :

Tocris Bioscience product webpage

product information

brand :

Tocris

master code :

5348

SKU :

5348/10

product name :

6,8-Bis(benzylthio)octanoic acid

description :

PDH and KGDH inhibitor

target :

Dehydrogenase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

388.59

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Pyruvate dehydrogenase (PDH) and -ketoglutarate dehydrogenase (KGDH) inhibitor. Disrupts tumor cell mitochondrial metabolism, and increases mitochondrial reactive oxygen species (ROS) production in H460 lung carcinoma cells. Has no effect on KGDH activity in normal bronchial epithelial cells. Induces cell death of multiple tumor cell lines selectively over normal cells in vitro . Inhibits tumor growth of H460 and BxPC-3 tumor cell xenografts in mice.

catalog number base :

5348

product keywords :

6,8-Bis(benzylthio)octanoic acid CPI613 Pyruvate dehydrogenase PDH a-ketoglutarate dehydrogenase alpha KGDH inhibitors inhibits antitumor active in vivo xenografts cell death Other Dehydrogenases 5348,

extended description :

PDH and KGDH inhibitor

chemical name text :

6,8-Bis[(phenylmethyl)thio]octanoic acid

formula :

C 22 H 28 O 2 S 2

formula text :

C22H28O2S2

cas num :

95809-78-2

2020 USD :

144

2021 USD :

150 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage