6,8-Bis(benzylthio)octanoic acid | Tocris Bioscience 5348/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

6,8-Bis(benzylthio)octanoic acid

catalog :

5348/10

quantity :

10 mg (also 50 mg)

price :

189 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Seegren P, Downs T, Stremska M, Harper L, Cao R, Olson R, et al. Mitochondrial Ca2+ Signaling Is an Electrometabolic Switch to Fuel Phagosome Killing. Cell Rep. 2020;33:108411 pubmed publisher

image

image 1 :

Cat.No. 5348 - 6,8-Bis(benzylthio)octanoic acid C22H28O2S2 CAS No. 95809-78-2

product information

brand :

Tocris

master code :

5348

SKU :

5348/10

product name :

6,8-Bis(benzylthio)octanoic acid

unit size :

10 mg (also 50 mg)

seo description :

PDH and KGDH inhibitor

target :

Dehydrogenase Inhibitors

category :

Small Molecules

purity :

99%

observed molecular weight :

388.59

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

6,8-Bis(benzylthio)octanoic acid is a pyruvate dehydrogenase (PDH) and -ketoglutarate dehydrogenase (KGDH) inhibitor. Disrupts tumor cell mitochondrial metabolism, and increases mitochondrial reactive oxygen species (ROS) production in H460 lung carcinoma cells. Has no effect on KGDH activity in normal bronchial epithelial cells. Induces cell death of multiple tumor cell lines selectively over normal cells in vitro . Inhibits tumor growth of H460 and BxPC-3 tumor cell xenografts in mice.

top caption :

PDH and KGDH inhibitor

extended description :

PDH and KGDH inhibitor

chemical name text :

6,8-Bis[(phenylmethyl)thio]octanoic acid

formula :

C22H28O2S2

formula text :

C22H28O2S2

cas num :

95809-78-2

USD :

189 USD

product details :

PDH and KGDH inhibitor

storage :

Store at +4░C

more info or order :

Tocris Bioscience product webpage