TPPB | Tocris Bioscience 5343/1 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

TPPB

catalog :

5343/1

quantity :

1 mg

price :

185 USD

more info or order :

Tocris Bioscience product webpage

citations: 6

Reference
Nair A, Traurig M, Sutherland J, Muller Y, Grellinger E, Saporito L, et al. Generation of Isogenic hiPSCs with Targeted Edits at Multiple Intronic SNPs to Study the Effects of the Type 2 Diabetes Associated KCNQ1 Locus in American Indians. Cells. 2022;11: pubmed publisher
Hogrebe N, Maxwell K, Augsornworawat P, Millman J. Generation of insulin-producing pancreatic β cells from multiple human stem cell lines. Nat Protoc. 2021;16:4109-4143 pubmed publisher
Ma H, Jeppesen J, Jaenisch R. Human T Cells Expressing a CD19 CAR-T Receptor Provide Insights into Mechanisms of Human CD19-Positive β Cell Destruction. Cell Rep Med. 2020;1:100097 pubmed publisher
Ghila L, Bjørlykke Y, Legøy T, Vethe H, Furuyama K, Chera S, et al. Bioinformatic Analyses of miRNA-mRNA Signature during hiPSC Differentiation towards Insulin-Producing Cells upon HNF4α Mutation. Biomedicines. 2020;8: pubmed publisher
Yang L, Han Y, Nilsson Payant B, Gupta V, Wang P, Duan X, et al. A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids. Cell Stem Cell. 2020;27:125-136.e7 pubmed publisher
Hogrebe N, Augsornworawat P, Maxwell K, Velazco Cruz L, Millman J. Targeting the cytoskeleton to direct pancreatic differentiation of human pluripotent stem cells. Nat Biotechnol. 2020;38:460-470 pubmed publisher

product information

brand :

Tocris

master code :

5343

SKU :

5343/1

product name :

TPPB

unit size :

1 mg

seo description :

High affinity PKC activator; also APP modulator

target :

Protein Kinase C Activators

category :

Small Molecules

purity :

98%

observed molecular weight :

501.54

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

TPPB is a high affinity and cell permeable protein kinase C activator (Ki =11.9 nM), which induces differentiation of hESCs into Pdx-1 expressing pancreatic progenitor cells. TPPB also enhances the non-amyloidgenic processing of amyloid precursor protein, increasing secretion of sAPP .

top caption :

High affinity PKC activator; also APP modulator

extended description :

High affinity PKC activator; also APP modulator

chemical name text :

(2E,4E)-N-[(2S,5S)-1,2,3,4,5,6-Hexahydro-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl)-3-oxo-1,4-benzodiazocin-8-yl]-5-[4-(trifluoromethyl)phenyl]-2,4-pentadienamide

formula :

C27H30F3N3O3

formula text :

C27H30F3N3O3

cas num :

497259-23-1

USD :

185 USD

product details :

High affinity PKC activator; also APP modulator

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage