chemical

PFK 15

5339

10 mg (also 50 mg)

145 USD

5339

5339/10

PFK 15

Selective PFKFB3 inhibitor

PFKFB3 Inhibitors

Small Molecules

10 mg (also 50 mg)

99%

260.29

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Originally reported to be a selective PFKFB3 inhibitor (IC50 = 207 nM); a more recent report failed to demonstrate activity in a PFKFB3 kinase assay. Selective for PFKFB3 over a panel of 96 kinases. Reduces glucose uptake and induces apoptosis in H522 lung adenocarcinoma and Jurkat T cell leukemia cells. Suppresses glucose uptake and tumor growth, and inhibits metastasis of Lewis lung carcinoma cell xenografts in mice.

5339

PFK15 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase selective PFKFB3 inhibitors inhibits antitumor PFKFB3 5339,

Selective PFKFB3 inhibitor

1-(4-Pyridinyl)-3-(2-quinolinyl)-2-propen-1-one

C 17 H 12 N 2 O

C17H12N2O

4382-63-2

142

145 USD

Store at -20°C