ML 365 | Tocris Bioscience 5337 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

ML 365

catalog :

5337

quantity :

10 mg (also 50 mg)

price :

180 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Pagani M, Albisetti G, Sivakumar N, Wildner H, Santello M, Johannssen H, et al. How Gastrin-Releasing Peptide Opens the Spinal Gate for Itch. Neuron. 2019;: pubmed publisher
Veldkamp M, Geuzebroek G, Baartscheer A, Verkerk A, Schumacher C, Suarez G, et al. Neurokinin-3 receptor activation selectively prolongs atrial refractoriness by inhibition of a background K+ channel. Nat Commun. 2018;9:4357 pubmed publisher
Vierra N, Dadi P, Milian S, Dickerson M, Jordan K, Gilon P, et al. TALK-1 channels control β cell endoplasmic reticulum Ca2+ homeostasis. Sci Signal. 2017;10: pubmed publisher

product information

brand :

Tocris

master code :

5337

SKU :

5337/10

product name :

ML 365

description :

Potent and selective K2P3.1 (TASK-1) channel blocker

target :

Two-P Potassium Channels Blockers

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

360.41

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and selective TASK-1 (K2P3.1/KCNK3) channel blocker (IC50 values are 4 and 390 nM at TASK-1 and TASK-3, respectively). Displays little or no inhibition at Kir2.1, voltage-gated potassium channels, KCNQ2 and KV11.1 (hERG).

catalog number base :

5337

product keywords :

ML365 Potassium channels subfamily K member 3 k2p3.1 KCNK3 potent selective TASK1 inhibitors inhibits TASK3 TWIK related acid sensitive K+ two pore potassium channel Two-P Potassium Channels 5337,

extended description :

Potent and selective K2P3.1 (TASK-1) channel blocker

chemical name text :

2-Methoxy-N-[3-[(3-methylbenzoyl)amino]phenyl]benzamide

formula :

C 22 H 20 N 2 O 3

formula text :

C22H20N2O3

cas num :

947914-18-3

2020 USD :

176

2021 USD :

180 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage