SP 141 | Tocris Bioscience 5332/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

SP 141

catalog :

5332/10

quantity :

10 mg (also 50 mg)

price :

233 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Zhang S, Xu H, Li W, Ji J, Jin Q, Chen L, et al. MDM2 promotes cancer cell survival through regulating the expression of HIF-1α and pVHL in retinoblastoma. Pathol Oncol Res. 2023;29:1610801 pubmed publisher
Klein A, Biderman L, Tong D, Alaghebandan B, Plumber S, Mueller H, et al. MDM2, MDMX, and p73 regulate cell-cycle progression in the absence of wild-type p53. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher

image

image 1 :

Cat.No. 5332 - SP 141 C22H16N2O CAS No. 1253491-42-7

product information

brand :

Tocris

master code :

5332

SKU :

5332/10

product name :

SP 141

unit size :

10 mg (also 50 mg)

seo description :

High affinity MDM2 inhibitor

target :

Ubiquitin Ligase (E3) Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

324.38

url print :

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details of functionality :

SP 141 is a high affinity MDM2 inhibitor (Ki = 28 nM); directly binds MDM2. SP 141 inhibits MDM2 expression and induces MDM2 autoubiquitination and proteasomal degradation. SP 141 attenuates growth of breast cancer xenograft tumors. SP 141 impairs liposarcoma growth in vitro and in human xenograft models. SP 141 is cell permeable.

top caption :

High affinity MDM2 inhibitor

extended description :

High affinity MDM2 inhibitor

chemical name text :

6-Methoxy-1-(1-naphthalenyl)-9H-pyrido[3,4-b]indole

formula :

C22H16N2O

formula text :

C22H16N2O

cas num :

1253491-42-7

USD :

233 USD

product details :

High affinity MDM2 inhibitor

storage :

Store at +4░C

more info or order :

Tocris Bioscience product webpage