CPI 203 | Tocris Bioscience 5331/10 product information

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product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

CPI 203

catalog :

5331/10

quantity :

10 mg

price :

354 USD

citations: 1

Reference
Shao Z, Yao C, Khodadadi Jamayran A, Xu W, Townes T, Crowley M, et al. Reprogramming by De-bookmarking the Somatic Transcriptional Program through Targeting of BET Bromodomains. Cell Rep. 2016;16:3138-3145 pubmed publisher

product information

brand :

Tocris

master code :

5331

SKU :

5331/10

product name :

CPI 203

target :

Bromodomain Inhibitors

category :

Small Molecules

unit sizes :

10 mg

purity :

98%

observed molecular weight :

399.9

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

CPI 203 is a BET bromodomain inhibitor. Downregulates Myc expression, causes G1 cell cycle arrest and attenuates cell proliferation in human pancreatic neuroendocrine tumors. Arrests the growth of T cell acute lymphoblastic leukemia cells in vitro (EC50 = 91.2 nM). Also enhances the antitumor effect of rapamycin (Cat. No. 1292) in vitro and attenuates rapamycin induced Akt activation. Also enhances fibroblast reprogramming to hiPSCs at low concentration. Orally bioavailable.

extended description :

BET bromodomain inhibitor; arrests cell cycle at G1 phase

chemical name text :

(6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide

formula :

C 19 H 18 ClN 5 OS

formula text :

C19H18ClN5OS

cas num :

1446144-04-2

USD :

354 USD

product details :

BET bromodomain inhibitor; arrests cell cycle at G1 phase

alt names :

TEN 010

storage :

Store at -20°C