AEG 40730 dihydrochloride | Tocris Bioscience 5330 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

AEG 40730 dihydrochloride

catalog :

5330

quantity :

10 mg (also 50 mg)

price :

290 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Beug S, Tang V, LaCasse E, Cheung H, Beauregard C, Brun J, et al. Smac mimetics and innate immune stimuli synergize to promote tumor death. Nat Biotechnol. 2014;32:182-90 pubmed publisher

product information

brand :

Tocris

master code :

5330

SKU :

5330/10

product name :

AEG 40730 dihydrochloride

description :

IAP antagonist; induces apoptosis

target :

IAP Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

97%

observed molecular weight :

1120.06

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

IAP antagonist; binds to the BIR3 domain of cIAP1, cIAP2 and XIAP with nanomolar affinity. Reduces cIAP1, cIAP2 and XIAP protein levels in human breast cancer MDA-MB-231 cells. Induces apoptosis in combination with TNF, and potentiates TRAIL-mediated apoptosis in human colorectal carcinoma HCT 116 cells. Cell permeable.

catalog number base :

5330

product keywords :

AEG40730 dihydrochloride 934963583 934963 58 3 IAP inhibitors inhibits apoptosis antagonists cIAP1 cIAP2 XIAP cellular BIR3 Apoptosis Inducers 5330,

extended description :

IAP antagonist; induces apoptosis

chemical name text :

222,Trifluoro-N-[[(2S)-1-(N-methyl-L-analyl-L-threonyl)-2-pyrrolidinyl]methyl]-N-(2-phenylethyl)acetamide, diethyl ether with 2,4-hexadiyne-1.6-diol dihydrochloride

formula :

C 52 H 68 F 6 N 8 O 8 .2HCl

formula text :

C52H68F6N8O8.2HCl

cas num :

1883545-50-3

2020 USD :

281

2021 USD :

290 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage