TY 52156 | Tocris Bioscience 5328 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

TY 52156

catalog :

5328

quantity :

10 mg (also 50 mg)

price :

184 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Heo J, Im D. Pro-Inflammatory Role of S1P3 in Macrophages. Biomol Ther (Seoul). 2019;27:373-380 pubmed publisher
Hübner K, Cabochette P, Diéguez Hurtado R, Wiesner C, Wakayama Y, Grassme K, et al. Wnt/β-catenin signaling regulates VE-cadherin-mediated anastomosis of brain capillaries by counteracting S1pr1 signaling. Nat Commun. 2018;9:4860 pubmed publisher
Ma S, Santhosh D, Kumar T P, Huang Z. A Brain-Region-Specific Neural Pathway Regulating Germinal Matrix Angiogenesis. Dev Cell. 2017;41:366-381.e4 pubmed publisher
Schuhmann M, Bittner S, Meuth S, Kleinschnitz C, Fluri F. Fingolimod (FTY720-P) Does Not Stabilize the Blood-Brain Barrier under Inflammatory Conditions in an in Vitro Model. Int J Mol Sci. 2015;16:29454-66 pubmed publisher
Hoffmann F, Hofereiter J, RÃ¼bsamen H, Melms J, Schwarz S, Faber H, et al. Fingolimod induces neuroprotective factors in human astrocytes. J Neuroinflammation. 2015;12:184 pubmed publisher

product information

brand :

Tocris

master code :

5328

SKU :

5328/10

product name :

TY 52156

description :

S1P3 receptor antagonist

target :

Sphingosine-1-phosphate Receptor Antagonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

364.27

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

S1P3 receptor antagonist (Ki = 110 nM); inhibits S1P-induced Ca2+ release in HUVEC cells. Suppresses FTY-720-induced S1P3 receptor-mediated bradycardia in vivo . Also inhibits S1P-induced breast cancer stem cell expansion in vitro . Orally bioavailable.

catalog number base :

5328

product keywords :

TY52156 S1P3 receptors antagonists antagonism sphingosine-1-phosphate Sphingosine-1-phosphate Receptors Cancer Stem Cells 5328,

extended description :

S1P3 receptor antagonist

chemical name text :

N-(4-Chlorophenyl)-3,3-dimethyl-2-oxobutanimidic 2-(4-chlorophenyl) hydrazide

formula :

C 18 H 19 Cl 2 N 3 O

formula text :

C18H19Cl2N3O

cas num :

934369-14-9

2020 USD :

176

2021 USD :

184 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage