BGC 20-1531 hydrochloride | Tocris Bioscience 5327 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

BGC 20-1531 hydrochloride

catalog :

5327

quantity :

10 mg

price :

332 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Perkins D, Richard K, Hansen A, Lai W, Nallar S, Koller B, et al. Autocrine-paracrine prostaglandin E2 signaling restricts TLR4 internalization and TRIF signaling. Nat Immunol. 2018;19:1309-1318 pubmed publisher

product information

brand :

Tocris

master code :

5327

SKU :

5327/10

product name :

BGC 20-1531 hydrochloride

description :

High affinity and selective EP4 antagonist

target :

Prostanoid Receptor Antagonists

category :

Small Molecules

unit size :

10 mg

purity :

98%

observed molecular weight :

529

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

High affinity and selective EP4 antagonist (Ki = 3 nM). Exhibits 2500-fold selectivity for EP4 over EP2 and EP3. Also selective over a range of other prostanoid receptors, ion channels, transporters and enzymes. Inhibits PGE2-induced vasodilation of middle cerebral and meningeal arteries in vitro , and carotid blood flow in vivo . Orally bioavailable.

catalog number base :

5327

product keywords :

BGC20-1531 hydrochloride PGN1531 high affinity selective EP4 antagonists orally bioavailable active PGN 1531 Prostanoid Receptors 5327,

extended description :

High affinity and selective EP4 antagonist

chemical name text :

4-[[4-(5-Methoxy-2-pyridinyl)phenoxy]methyl]-5-methyl-N-[(2-methylphenyl)sulfonyl]-2-furancarboxamide hydrochloride

formula :

C 26 H 24 N 2 O 6 S.HCl

formula text :

C26H24N2O6S.HCl

cas num :

1962928-26-2

2020 USD :

322

2021 USD :

332 USD

alt names :

PGN 1531

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage