BGC 20-1531 hydrochloride | Tocris Bioscience 5327/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

BGC 20-1531 hydrochloride

catalog :

5327/10

quantity :

10 mg

price :

417 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Chae C, Sandoval T, Hwang S, Park E, Giovanelli P, Awasthi D, et al. Tumor-Derived Lysophosphatidic Acid Blunts Protective Type I Interferon Responses in Ovarian Cancer. Cancer Discov. 2022;12:1904-1921 pubmed publisher
Perkins D, Richard K, Hansen A, Lai W, Nallar S, Koller B, et al. Autocrine-paracrine prostaglandin E2 signaling restricts TLR4 internalization and TRIF signaling. Nat Immunol. 2018;19:1309-1318 pubmed publisher

image

image 1 :

Cat.No. 5327 - BGC 20-1531 hydrochloride C26H24N2O6S.HCl CAS No. 1962928-26-2

product information

brand :

Tocris

master code :

5327

SKU :

5327/10

product name :

BGC 20-1531 hydrochloride

unit size :

10 mg

seo description :

High affinity and selective EP4 antagonist

target :

Prostanoid Receptor Antagonists

category :

Small Molecules

purity :

98%

observed molecular weight :

529

url print :

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details of functionality :

BGC 20-1531 hydrochloride is a high affinity and selective EP4 antagonist (Ki = 3 nM). Exhibits 2500-fold selectivity for EP4 over EP2 and EP3. Also selective over a range of other prostanoid receptors, ion channels, transporters and enzymes. Inhibits PGE2-induced vasodilation of middle cerebral and meningeal arteries in vitro , and carotid blood flow in vivo . Orally bioavailable.

top caption :

High affinity and selective EP4 antagonist

extended description :

High affinity and selective EP4 antagonist

chemical name text :

4-[[4-(5-Methoxy-2-pyridinyl)phenoxy]methyl]-5-methyl-N-[(2-methylphenyl)sulfonyl]-2-furancarboxamide hydrochloride

formula :

C26H24N2O6S.HCl

formula text :

C26H24N2O6S.HCl

cas num :

1962928-26-2

USD :

417 USD

product details :

High affinity and selective EP4 antagonist

alt names :

PGN 1531

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage