Rosiglitazone | Tocris Bioscience 5325/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Rosiglitazone

catalog :

5325/10

quantity :

10 mg (also 50 mg)

price :

93 USD

more info or order :

Tocris Bioscience product webpage

citations: 16

Reference
Kalkan H, Pagano E, Paris D, Panza E, Cuozzo M, Moriello C, et al. Targeting gut dysbiosis against inflammation and impaired autophagy in Duchenne muscular dystrophy. EMBO Mol Med. 2023;15:e16225 pubmed publisher
Shen M, Manca C, Suriano F, Nallabelli N, Pechereau F, Allam Ndoul B, et al. Three of a Kind: Control of the Expression of Liver-Expressed Antimicrobial Peptide 2 (LEAP2) by the Endocannabinoidome and the Gut Microbiome. Molecules. 2021;27: pubmed publisher
Zhong S, Zhou Z, Lin X, Liu F, Liu C, Liu Z, et al. Ketogenic diet prevents paclitaxel-induced neuropathic nociception through activation of PPARγ signalling pathway and inhibition of neuroinflammation in rat dorsal root ganglion. Eur J Neurosci. 2021;54:5341-5356 pubmed publisher
Depommier C, Vitale R, Iannotti F, Silvestri C, Flamand N, Druart C, et al. Beneficial Effects of Akkermansia muciniphila Are Not Associated with Major Changes in the Circulating Endocannabinoidome but Linked to Higher Mono-Palmitoyl-Glycerol Levels as New PPARα Agonists. Cells. 2021;10: pubmed publisher
Zhang L, Avery J, Yin A, Singh A, Cliff T, Yin H, et al. Generation of Functional Brown Adipocytes from Human Pluripotent Stem Cells via Progression through a Paraxial Mesoderm State. Cell Stem Cell. 2020;27:784-797.e11 pubmed publisher
Iannotti F, De Maio F, Panza E, Appendino G, Taglialatela Scafati O, De Petrocellis L, et al. Identification and Characterization of Cannabimovone, a Cannabinoid from Cannabis sativa, as a Novel PPARγ Agonist via a Combined Computational and Functional Study. Molecules. 2020;25: pubmed publisher
Fellous T, De Maio F, Kalkan H, Carannante B, Boccella S, Petrosino S, et al. Phytocannabinoids promote viability and functional adipogenesis of bone marrow-derived mesenchymal stem cells through different molecular targets. Biochem Pharmacol. 2020;175:113859 pubmed publisher
Smith D, Martinelli R, Besra G, Illarionov P, Szatmari I, Brazda P, et al. Identification and characterization of a novel anti-inflammatory lipid isolated from Mycobacterium vaccae, a soil-derived bacterium with immunoregulatory and stress resilience properties. Psychopharmacology (Berl). 2019;: pubmed publisher
Brust R, Shang J, Fuhrmann J, Mosure S, Bass J, Cano A, et al. A structural mechanism for directing corepressor-selective inverse agonism of PPARγ. Nat Commun. 2018;9:4687 pubmed publisher
Vitale R, D Aniello E, Gorbi S, Martella A, Silvestri C, Giuliani M, et al. Fishing for Targets of Alien Metabolites: A Novel Peroxisome Proliferator-Activated Receptor (PPAR) Agonist from a Marine Pest. Mar Drugs. 2018;16: pubmed publisher
Rondón Ortiz A, Lino Cardenas C, Martínez Málaga J, Gonzales Urday A, Gugnani K, Böhlke M, et al. High Concentrations of Rosiglitazone Reduce mRNA and Protein Levels of LRP1 in HepG2 Cells. Front Pharmacol. 2017;8:772 pubmed publisher
Ganti K, Mukherji A, Surjit M, Li M, Chambon P. Similarities and differences in the transcriptional control of expression of the mouse TSLP gene in skin epidermis and intestinal epithelium. Proc Natl Acad Sci U S A. 2017;114:E951-E960 pubmed publisher
Warrick J, Walter V, Yamashita H, Chung E, Shuman L, Amponsa V, et al. FOXA1, GATA3 and PPAR? Cooperate to Drive Luminal Subtype in Bladder Cancer: A Molecular Analysis of Established Human Cell Lines. Sci Rep. 2016;6:38531 pubmed publisher
Matsa E, Burridge P, Yu K, Ahrens J, Termglinchan V, Wu H, et al. Transcriptome Profiling of Patient-Specific Human iPSC-Cardiomyocytes Predicts Individual Drug Safety and Efficacy Responses InÂ Vitro. Cell Stem Cell. 2016;19:311-25 pubmed publisher
Ahlem C, Kennedy M, Page T, Reading C, White S, McKenzie J, et al. Studies of the pharmacology of 17?-ethynyl-androst-5-ene-3?,7?,17?-triol, a synthetic anti-inflammatory androstene. Int J Clin Exp Med. 2011;4:119-35 pubmed
Yang H, Youm Y, Dixit V. Inhibition of thymic adipogenesis by caloric restriction is coupled with reduction in age-related thymic involution. J Immunol. 2009;183:3040-52 pubmed publisher

product information

brand :

Tocris

master code :

5325

SKU :

5325/10

product name :

Rosiglitazone

unit size :

10 mg (also 50 mg)

seo description :

Potent and selective PPAR agonist; antidiabetic agent

target :

PPAR gamma Receptor Agonists

category :

Small Molecules

purity :

98%

observed molecular weight :

357.43

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Rosiglitazone is a potent and selective PPAR agonist (EC50 = 60 nM); exhibits no activity at PPAR and PPAR . Promotes differentiation of pluripotent C3H10T1/2 stem cells into adipocytes. Also promotes differentiation of urothelial organoids in combination with Erlotinib (Cat. No. 7194). Exhibits antihyperglycemic activity in diabetic ob/ob mouse model. Antidiabetic agent.

top caption :

Potent and selective PPAR agonist; antidiabetic agent

extended description :

Potent and selective PPAR agonist; antidiabetic agent

chemical name text :

5-[[4-[2-(Methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione

formula :

C18H19N3O3S

formula text :

C18H19N3O3S

cas num :

122320-73-4

USD :

93 USD

product details :

Potent and selective PPAR agonist; antidiabetic agent

alt names :

BRL 49653

storage :

Store at +4░C

more info or order :

Tocris Bioscience product webpage