AEE 788 | Tocris Bioscience 5318 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

AEE 788

catalog :

5318

quantity :

10 mg (also 50 mg)

price :

260 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Bill A, Gutierrez A, Kulkarni S, Kemp C, Bonenfant D, Voshol H, et al. ANO1/TMEM16A interacts with EGFR and correlates with sensitivity to EGFR-targeting therapy in head and neck cancer. Oncotarget. 2015;6:9173-88 pubmed

product information

brand :

Tocris

master code :

5318

SKU :

5318/10

product name :

AEE 788

description :

Potent EGFR and VEGFR inhibitor

target :

EGF Receptor Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

440.58

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent EGFR and VEGFR inhibitor (IC50 values are 2, 6, 59, 77, 160 and 330 nM for EGFR, ErbB2, VEGFR-1, VEGFR-2, ErbB4 and VEGFR-3 respectively). Also inhibits c-Abl, c-Fms and c-Src (IC50 values are 52, 60 and 61 nM respectively). Inhibits proliferation of EGFR and ErbB2 overexpressing cancer cell lines in vitro . Inhibits tumor xenograft growth and VEGF-induced angiogenesis in mice. Orally active.

catalog number base :

5318

product keywords :

AEE788 potent epidermal vascular endothelial growth factors EGFR VEGFR ErbB2 antiangiogenic antitumor orally active EGFR VEGFR 5318,

extended description :

Potent EGFR and VEGFR inhibitor

chemical name text :

6-[4-[(4-Ethyl-1-piperazinyl)methyl]phenyl]-N-[(1R)-1-phenylethyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine

formula :

C 27 H 32 N 6

formula text :

C27H32N6

cas num :

497839-62-0

2020 USD :

254

2021 USD :

260 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage