SMBA 1 | Tocris Bioscience 5314 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

SMBA 1

catalog :

5314

quantity :

10 mg (also 50 mg)

price :

199 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Xin M, Li R, Xie M, Park D, Owonikoko T, Sica G, et al. Small-molecule Bax agonists for cancer therapy. Nat Commun. 2014;5:4935 pubmed publisher

product information

brand :

Tocris

master code :

5314

SKU :

5314/10

product name :

SMBA 1

description :

High affinity and selective activator of Bax

target :

Bcl-2 Family Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

315.32

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

High affinity and selective activator of Bax (Ki = 43.3 nM). Binds to the S184 binding pocket to block Bax phosphorylation. Does not bind to other Bcl-2 family members, including Bcl-2, Bak and Bid. Facilitates Bax insertion into the mitochondrial membrane and promotes Bax-dependent cytochrome c release. Induces apoptosis in lung cancer cell lines expressing high levels of Bax selectively over normal cells expressing low levels of Bax. Represses tumor growth of A549 lung cancer xenografts in mice.

catalog number base :

5314

product keywords :

SMBA1 high affinity selective bax activator bcl-2 family apoptosis cytochrome c release Bcl-2 Family Apoptosis Inducers 5314,

extended description :

High affinity and selective activator of Bax

chemical name text :

2-[(2-Nitro-9H-fluorene-9-ylidene)methyl]phenol

formula :

C 20 H 13 NO 3

formula text :

C20H13NO3

cas num :

906440-37-7

2020 USD :

195

2021 USD :

199 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage