SMBA 1 | Tocris Bioscience 5314/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

SMBA 1

catalog :

5314/10

quantity :

10 mg (also 50 mg)

price :

250 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Xin M, Li R, Xie M, Park D, Owonikoko T, Sica G, et al. Small-molecule Bax agonists for cancer therapy. Nat Commun. 2014;5:4935 pubmed publisher

product information

brand :

Tocris

master code :

5314

SKU :

5314/10

product name :

SMBA 1

unit size :

10 mg (also 50 mg)

seo description :

High affinity and selective activator of Bax

target :

Bcl-2 Family Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

315.32

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

SMBA 1 is a high affinity and selective activator of Bax (Ki = 43.3 nM). Binds to the S184 binding pocket to block Bax phosphorylation. Does not bind to other Bcl-2 family members, including Bcl-2, Bak and Bid. Facilitates Bax insertion into the mitochondrial membrane and promotes Bax-dependent cytochrome c release. Induces apoptosis in lung cancer cell lines expressing high levels of Bax selectively over normal cells expressing low levels of Bax. Represses tumor growth of A549 lung cancer xenografts in mice.

top caption :

High affinity and selective activator of Bax

extended description :

High affinity and selective activator of Bax

chemical name text :

2-[(2-Nitro-9H-fluorene-9-ylidene)methyl]phenol

formula :

C20H13NO3

formula text :

C20H13NO3

cas num :

906440-37-7

USD :

250 USD

product details :

High affinity and selective activator of Bax

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage