chemical

SP 100030

5309

10 mg (also 50 mg)

212 USD

5309

5309/10

SP 100030

NF- B and AP-1 dual inhibitor

NFkB/IkB Inhibitors

Small Molecules

10 mg (also 50 mg)

99%

437.65

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Potent dual inhibitor of NF- B and AP-1 transcriptional activity (IC50 = 50 nM). Blocks production of IL-2, IL-8 and TNF- from Jurkat T cells. Inhibits cytokine production selectively in T cells; exhibits minimal inhibition of cytokine production in other cell types. Decreases arthritic severity in a mouse model of collagen-induced arthritis. Also ameliorates muscle wasting in a rat model of cancer cachexia.

5309

SP100030 potent dual inhibitors inhibits nf-kb nf-kappab nf- b blocks cytokine production selective t cells immunosuppressive anti-inflammatory NF-kB/IkB AP-1 5309,

NF- B and AP-1 dual inhibitor

N-[3,5-Bis(trifluoromethyl)phenyl]-2-chloro-4-(trifluoromethyl)-5-pyrimidinecarboxamide

C 14 H 5 ClF 9 N 3 O

C14H5ClF9N3O

154563-54-9

203

212 USD

Store at +4°C