SP 100030 | Tocris Bioscience 5309/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

SP 100030

catalog :

5309/10

quantity :

10 mg (also 50 mg)

price :

267 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Chae C, Sandoval T, Hwang S, Park E, Giovanelli P, Awasthi D, et al. Tumor-Derived Lysophosphatidic Acid Blunts Protective Type I Interferon Responses in Ovarian Cancer. Cancer Discov. 2022;12:1904-1921 pubmed publisher
Soto D xed az K, Juda M, Blackmore S, Walsh C, Steelman A. TAK1 inhibition in mouse astrocyte cultures ameliorates cytokine-induced chemokine production and neutrophil migration. J Neurochem. 2020;152:697-709 pubmed publisher
Yoon H, Ko Y. LMP1+SLAMF1high cells are associated with drug resistance in Epstein-Barr virus-positive Farage cells. Oncotarget. 2017;8:24621-24634 pubmed publisher

product information

brand :

Tocris

master code :

5309

SKU :

5309/10

product name :

SP 100030

unit size :

10 mg (also 50 mg)

seo description :

NF- B and AP-1 dual inhibitor

target :

NFkB/IkB Inhibitors

category :

Small Molecules

purity :

99%

observed molecular weight :

437.65

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

SP 100030 is a potent dual inhibitor of NF- B and AP-1 transcriptional activity (IC50 = 50 nM). Blocks production of IL-2, IL-8 and TNF- from Jurkat T cells. Inhibits cytokine production selectively in T cells; exhibits minimal inhibition of cytokine production in other cell types. Decreases arthritic severity in a mouse model of collagen-induced arthritis. Also ameliorates muscle wasting in a rat model of cancer cachexia.

top caption :

NF- B and AP-1 dual inhibitor

extended description :

NF- B and AP-1 dual inhibitor

chemical name text :

N-[3,5-Bis(trifluoromethyl)phenyl]-2-chloro-4-(trifluoromethyl)-5-pyrimidinecarboxamide

formula :

C14H5ClF9N3O

formula text :

C14H5ClF9N3O

cas num :

154563-54-9

USD :

267 USD

product details :

NF- B and AP-1 dual inhibitor

storage :

Store at +4░C

more info or order :

Tocris Bioscience product webpage