MM 102 | Tocris Bioscience 5307/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

MM 102

catalog :

5307/10

quantity :

10 mg

price :

360 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Eastman A, Xu J, Bermik J, Potchen N, den Dekker A, Neal L, et al. Epigenetic stabilization of DC and DC precursor classical activation by TNFα contributes to protective T cell polarization. Sci Adv. 2019;5:eaaw9051 pubmed publisher
Shimoda H, Doi S, Nakashima A, Sasaki K, Doi T, Masaki T. Inhibition of the H3K4 methyltransferase MLL1/WDR5 complex attenuates renal senescence in ischemia reperfusion mice by reduction of p16INK4a. Kidney Int. 2019;96:1162-1175 pubmed publisher

product information

brand :

Tocris

master code :

5307

SKU :

5307/10

product name :

MM 102

unit size :

10 mg

seo description :

Potent WDR5/MLL interaction inhibitor

target :

Additional Lysine Methyltransferase Compounds

category :

Small Molecules

purity :

95%

observed molecular weight :

783.83

url print :

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details of functionality :

MM 102 is a potent WDR5/MLL interaction inhibitor (IC50 = 2.4 nM). Inhibits MLL1 methyltransferase activity and MLL-1-induced HoxA9 and Meis-1 gene expression in leukemia cells expressing the MLL1-AF9 fusion gene. Also inhibits cell growth and induces apoptosis in leukemia cells harbouring MLL1 fusion proteins.

top caption :

Potent WDR5/MLL interaction inhibitor

extended description :

Potent WDR5/MLL interaction inhibitor

chemical name text :

1-[[(2S)-5-[(Aminoiminomethyl)amino]-2-[[2-ethyl-2-[(2-methyl-1-oxopropyl)amino]-1-oxobutyl]amino]-1-oxopentyl]amino]-N-[bis(4-fluorophenyl)methyl]-cyclopentanecarboxamide trifluoroacetate

formula :

C35H49F2N7O4.CF3CO2H

formula text :

C35H49F2N7O4.CF3CO2H

cas num :

1883545-52-5

USD :

360 USD

product details :

Potent WDR5/MLL interaction inhibitor

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage