Verteporfin | Tocris Bioscience 5305 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Verteporfin

catalog :

5305

quantity :

10 mg

price :

192 USD

more info or order :

Tocris Bioscience product webpage

citations: 7

Reference
Li R, Zhong C, Yu Y, Liu H, Sakurai M, Yu L, et al. Generation of Blastocyst-like Structures from Mouse Embryonic and Adult Cell Cultures. Cell. 2019;179:687-702.e18 pubmed publisher
An Y, Adams J, Hollern D, Zhao A, Chang S, Gams M, et al. Cdh1 and Pik3ca Mutations Cooperate to Induce Immune-Related Invasive Lobular Carcinoma of the Breast. Cell Rep. 2018;25:702-714.e6 pubmed publisher
Eales K, Wilkinson E, Cruickshank G, Tucker J, Tennant D. Verteporfin selectively kills hypoxic glioma cells through iron-binding and increased production of reactive oxygen species. Sci Rep. 2018;8:14358 pubmed publisher
Kato K, Diéguez Hurtado R, Park D, Hong S, Kato Azuma S, Adams S, et al. Pulmonary pericytes regulate lung morphogenesis. Nat Commun. 2018;9:2448 pubmed publisher
Yosefzon Y, Soteriou D, Feldman A, Kostić L, Koren E, Brown S, et al. Caspase-3 Regulates YAP-Dependent Cell Proliferation and Organ Size. Mol Cell. 2018;70:573-587.e4 pubmed publisher
Fisher M, Grun D, Adhikary G, Xu W, Eckert R. Inhibition of YAP function overcomes BRAF inhibitor resistance in melanoma cancer stem cells. Oncotarget. 2017;8:110257-110272 pubmed publisher
Seong B, Fathers K, Hallett R, Yung C, Stein L, Mouaaz S, et al. A Metastatic Mouse Model Identifies Genes That Regulate Neuroblastoma Metastasis. Cancer Res. 2017;77:696-706 pubmed publisher

product information

brand :

Tocris

master code :

5305

SKU :

5305/10

product name :

Verteporfin

description :

YAP inhibitor

target :

Additional Transcription Factor Compounds

category :

Small Molecules

unit size :

10 mg

purity :

97%

observed molecular weight :

718.79

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

YAP inhibitor; disrupts YAP-TEAD interactions. Enhances trypsin cleavage of YAP (EC50 = 100 nM). Inhibits growth and proliferation of retinoblastoma cells. Also suppresses cancer stem cell properties in vitro . Suppresses YAP-induced liver overgrowth in mice.

catalog number base :

5305

product keywords :

YAP yes associated protein hippo inhibits inhibitors TEAD Visudyne Cancer Stem Cells Hippo/Yap signaling 5305,

extended description :

YAP inhibitor

chemical name text :

(4R,4aS)-18-Ethenyl-4,4a-dihydro-3,4-bis(methoxycarbonyl)-4a,8,14,19-tetramethyl-24H,26H-benzo[b]porphine-9,13-dipropanoic acid monomethyl ester

formula :

C 41 H 42 N 4 O 8

formula text :

C41H42N4O8

cas num :

129497-78-5

2020 USD :

188

2021 USD :

192 USD

alt names :

Visudyne

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage