Verteporfin | Tocris Bioscience 5305/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Verteporfin

catalog :

5305/10

quantity :

10 mg

price :

250 USD

more info or order :

Tocris Bioscience product webpage

citations: 14

Reference
Howard A, Bojko J, Flynn B, Bowen S, Jungwirth U, Walko G. Targeting the Hippo/YAP/TAZ signalling pathway: Novel opportunities for therapeutic interventions into skin cancers. Exp Dermatol. 2022;31:1477-1499 pubmed publisher
Stancil I, Michalski J, Davis Hall D, Chu H, Park J, Magin C, et al. Pulmonary fibrosis distal airway epithelia are dynamically and structurally dysfunctional. Nat Commun. 2021;12:4566 pubmed publisher
Xu Z, Orkwis J, Harris G. Cell Shape and Matrix Stiffness Impact Schwann Cell Plasticity via YAP/TAZ and Rho GTPases. Int J Mol Sci. 2021;22: pubmed publisher
Tulasi D, Castaneda D, Wager K, Hogan C, Alcedo K, Raab J, et al. Sox9EGFP Defines Biliary Epithelial Heterogeneity Downstream of Yap Activity. Cell Mol Gastroenterol Hepatol. 2021;11:1437-1462 pubmed publisher
Dong C, Beltcheva M, Gontarz P, Zhang B, Popli P, Fischer L, et al. Derivation of trophoblast stem cells from naïve human pluripotent stem cells. elife. 2020;9: pubmed publisher
Li R, Zhong C, Yu Y, Liu H, Sakurai M, Yu L, et al. Generation of Blastocyst-like Structures from Mouse Embryonic and Adult Cell Cultures. Cell. 2019;179:687-702.e18 pubmed publisher
Dang D, Makena M, Llongueras J, Prasad H, Ko M, Bandral M, et al. A Ca2+-ATPase Regulates E-cadherin Biogenesis and Epithelial-Mesenchymal Transition in Breast Cancer Cells. Mol Cancer Res. 2019;: pubmed publisher
Wang K, Wang C, Dai L, Yang J, Huang H, Ma X, et al. Targeting an Autocrine Regulatory Loop in Cancer Stem-like Cells Impairs the Progression and Chemotherapy Resistance of Bladder Cancer. Clin Cancer Res. 2019;25:1070-1086 pubmed publisher
An Y, Adams J, Hollern D, Zhao A, Chang S, Gams M, et al. Cdh1 and Pik3ca Mutations Cooperate to Induce Immune-Related Invasive Lobular Carcinoma of the Breast. Cell Rep. 2018;25:702-714.e6 pubmed publisher
Eales K, Wilkinson E, Cruickshank G, Tucker J, Tennant D. Verteporfin selectively kills hypoxic glioma cells through iron-binding and increased production of reactive oxygen species. Sci Rep. 2018;8:14358 pubmed publisher
Kato K, Diéguez Hurtado R, Park D, Hong S, Kato Azuma S, Adams S, et al. Pulmonary pericytes regulate lung morphogenesis. Nat Commun. 2018;9:2448 pubmed publisher
Yosefzon Y, Soteriou D, Feldman A, Kostić L, Koren E, Brown S, et al. Caspase-3 Regulates YAP-Dependent Cell Proliferation and Organ Size. Mol Cell. 2018;70:573-587.e4 pubmed publisher
Fisher M, Grun D, Adhikary G, Xu W, Eckert R. Inhibition of YAP function overcomes BRAF inhibitor resistance in melanoma cancer stem cells. Oncotarget. 2017;8:110257-110272 pubmed publisher
Seong B, Fathers K, Hallett R, Yung C, Stein L, Mouaaz S, et al. A Metastatic Mouse Model Identifies Genes That Regulate Neuroblastoma Metastasis. Cancer Res. 2017;77:696-706 pubmed publisher

product information

brand :

Tocris

master code :

5305

SKU :

5305/10

product name :

Verteporfin

unit size :

10 mg

seo description :

YAP inhibitor

target :

Additional Transcription Factor Compounds

category :

Small Molecules

purity :

95%

observed molecular weight :

718.79

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Verteporfin is a YAP inhibitor; disrupts YAP-TEAD interactions. Enhances trypsin cleavage of YAP (EC50 = 100 nM). Inhibits growth and proliferation of retinoblastoma cells. Also suppresses cancer stem cell properties in vitro . Suppresses YAP-induced liver overgrowth in mice.

top caption :

YAP inhibitor

extended description :

YAP inhibitor

chemical name text :

(4R,4aS)-18-Ethenyl-4,4a-dihydro-3,4-bis(methoxycarbonyl)-4a,8,14,19-tetramethyl-24H,26H-benzo[b]porphine-9,13-dipropanoic acid monomethyl ester

formula :

C41H42N4O8

formula text :

C41H42N4O8

cas num :

129497-78-5

USD :

250 USD

product details :

YAP inhibitor

alt names :

Visudyne

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage