product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
FICZ
catalog :
5304/1
quantity :
1 mg
price :
223 USD
more info or order :
citations: 6
Reference
Sanmarco L, Chao C, Wang Y, Kenison J, Li Z, Rone J, et al. Identification of environmental factors that promote intestinal inflammation. Nature. 2022;611:801-809 pubmed publisher
Lopez D, Al Jaberi F, Woetmann A, xd8 dum N, Bonefeld C, Kongsbak Wismann M, et al. Macrophages Control the Bioavailability of Vitamin D and Vitamin D-Regulated T Cell Responses. Front Immunol. 2021;12:722806 pubmed publisher
Lopez D, Al Jaberi F, Damas N, Weinert B, Pus U, Torres Rusillo S, et al. Vitamin D Inhibits IL-22 Production Through a Repressive Vitamin D Response Element in the il22 Promoter. Front Immunol. 2021;12:715059 pubmed publisher
Walczak K, Langner E, Makuch Kocka A, Szelest M, Szalast K, Marciniak S, et al. Effect of Tryptophan-Derived AhR Ligands, Kynurenine, Kynurenic Acid and FICZ, on Proliferation, Cell Cycle Regulation and Cell Death of Melanoma Cells-In Vitro Studies. Int J Mol Sci. 2020;21: pubmed publisher
Alves de Lima K, Rustenhoven J, Dá Mesquita S, Wall M, Salvador A, Smirnov I, et al. Meningeal γδ T cells regulate anxiety-like behavior via IL-17a signaling in neurons. Nat Immunol. 2020;21:1421-1429 pubmed publisher
Giani Tagliabue S, Faber S, Motta S, Denison M, Bonati L. Modeling the binding of diverse ligands within the Ah receptor ligand binding domain. Sci Rep. 2019;9:10693 pubmed publisher
image
image 1 :
Tocris Bioscience 5304/1 image 1
Cat.No. 5304 - FICZ C19H12N2O CAS No. 172922-91-7
product information
brand :
Tocris
master code :
5304
SKU :
5304/1
product name :
FICZ
unit size :
1 mg
seo description :
High affinity aryl hydrocarbon receptor (AhR) agonist
target :
Aryl Hydrocarbon Receptor Agonists
category :
Small Molecules
purity :
95%
observed molecular weight :
284.31
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
FICZ is a high affinity aryl hydrocarbon receptor (AhR) agonist (Kd = 70 pM). Proposed to be an endogenous AhR ligand. Induces transient expression of cytochrome P450-1A1 (CYP1A1) in vitro .
top caption :
High affinity aryl hydrocarbon receptor (AhR) agonist
extended description :
High affinity aryl hydrocarbon receptor (AhR) agonist
chemical name text :
5,11-Dihydroindolo[3,2-b]carbazole-6-carboxaldehyde
formula :
C19H12N2O
formula text :
C19H12N2O
cas num :
172922-91-7
USD :
223 USD
product details :
High affinity aryl hydrocarbon receptor (AhR) agonist
storage :
Store at -20░C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK