JNJ 47965567 | Tocris Bioscience 5299 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

JNJ 47965567

catalog :

5299

quantity :

10 mg (also 50 mg)

price :

220 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Uderhardt S, Martins A, Tsang J, Lämmermann T, Germain R. Resident Macrophages Cloak Tissue Microlesions to Prevent Neutrophil-Driven Inflammatory Damage. Cell. 2019;177:541-555.e17 pubmed publisher

product information

brand :

Tocris

master code :

5299

SKU :

5299/10

product name :

JNJ 47965567

description :

Potent and selective P2X7 antagonist; brain penetrant

target :

P2X Receptor Antagonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

488.64

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and selective P2X7 antagonist (pIC50 values are 8.3, 7.5 and 7.2 for human, mouse and rat receptors respectively). Selective over a panel of 50 other receptors, ion channels and transporters. Reduces BzATP -induced IL-1 release from monocytes in vitro and from rat brain in vivo . Attenuates amphetamine -induced hyperactivity in rats. Brain penetrant.

catalog number base :

5299

product keywords :

JNJ47965567 potent selective p2x7 purinergics antagonists brain penetrant P2X Receptors 5299,

extended description :

Potent and selective P2X7 antagonist; brain penetrant

chemical name text :

2-(Phenylthio)-N-[[tetrahydro-4-(4-phenyl-1-piperazinyl)-2H-pyran-4-yl]methyl-3-pyridinecarboxamide

formula :

C 28 H 32 N 4 O 2 S

formula text :

C28H32N4O2S

cas num :

1428327-31-4

2020 USD :

209

2021 USD :

220 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage