JNJ 47965567 | Tocris Bioscience 5299/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

JNJ 47965567

catalog :

5299/10

quantity :

10 mg (also 50 mg)

price :

283 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Francistiov xe1 L, V xf6 r xf6 s K, Lov xe1 sz Z, Dinny xe9 s A, Kobol xe1 k J. Detection and Functional Evaluation of the P2X7 Receptor in hiPSC Derived Neurons and Microglia-Like Cells. Front Mol Neurosci. 2021;14:793769 pubmed publisher
McEwan T, Sophocleous R, Cuthbertson P, Mansfield K, Sanderson Smith M, Sluyter R. Autocrine regulation of wound healing by ATP release and P2Y2 receptor activation. Life Sci. 2021;283:119850 pubmed publisher
Uderhardt S, Martins A, Tsang J, Lämmermann T, Germain R. Resident Macrophages Cloak Tissue Microlesions to Prevent Neutrophil-Driven Inflammatory Damage. Cell. 2019;177:541-555.e17 pubmed publisher
Dos Santos Pereira M, Acu xf1 a L, Hamadat S, Rocca J, Gonz xe1 lez Liz xe1 rraga F, Cheh xed n R, et al. Microglial glutamate release evoked by α-synuclein aggregates is prevented by dopamine. Glia. 2018;66:2353-2365 pubmed publisher

product information

brand :

Tocris

catalog number base :

5299

SKU :

5299/10

product name :

JNJ 47965567

units size :

10 mg (also 50 mg)

description :

Potent and selective P2X7 antagonist; brain penetrant

target :

P2X Receptor Antagonists

category :

Small Molecules

purity :

98%

observed molecular weight :

488.64

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

review stars :

details of functionality :

JNJ 47965567 is a potent and selective P2X7 antagonist (pIC50 values are 8.3, 7.5 and 7.2 for human, mouse and rat receptors respectively). Selective over a panel of 50 other receptors, ion channels and transporters. Reduces BzATP -induced IL-1 release from monocytes in vitro and from rat brain in vivo . Attenuates amphetamine -induced hyperactivity in rats. Brain penetrant.

top caption :

Potent and selective P2X7 antagonist; brain penetrant

extended description :

Potent and selective P2X7 antagonist; brain penetrant

chemical name text :

2-(Phenylthio)-N-[[tetrahydro-4-(4-phenyl-1-piperazinyl)-2H-pyran-4-yl]methyl-3-pyridinecarboxamide

formula :

C28H32N4O2S

formula text :

C28H32N4O2S

cas num :

1428327-31-4

USD :

283 USD

product details :

Potent and selective P2X7 antagonist; brain penetrant

storage :

Store at +4Â°C

more info or order :

Tocris Bioscience product webpage