chemical

LY 404187

5297

10 mg (also 50 mg)

210 USD

5297

5297/10

LY 404187

Selective positive allosteric modulator of AMPA receptors

AMPA Receptor Modulators

Small Molecules

10 mg (also 50 mg)

98%

342.46

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Selective AMPA receptor positive allosteric modulator (IC50 values are 0.15, 0.21, 1.66 and 5.65 M for GluA2i, GluA4i, GluA3i and GluA1i respectively). Potentiates glutamate and AMPA-evoked currents in pre frontal cortex (PFC) pyramidal neurons in vitro . Has no effect on NMDA- or kainate-evoked currents; also has no effect on K+ or Na+ ion channels. Potentiates PFC glutamatergic synaptic transmission in vitro and in vivo . Induces neurite growth in combination with ( S )-AMPA (Cat. No. 0254) in SH-SY5Y human neuroblastoma cells in vitro . Also reduces MPTP-induced toxicity in mice. Brain penetrant.

5297

LY404187 selective ampa receptors positive allosteric modulators PAMs GLUA1 GLUA2 GLUA3 GLUA4 GLUR1 GLUR2 GLUR3 GLUR4 parkinson disease depression memory AMPA Receptors 5297,

Selective positive allosteric modulator of AMPA receptors

N-[2-(4 -Cyano[1,1 -biphenyl]-4-yl)propyl]-2-propanesulfonamide

C 19 H 22 N 2 O 2 S

C19H22N2O2S

211311-95-4

203

210 USD

Store at +4°C