chemical

LY 404187

5297/10

10 mg (also 50 mg)

265 USD

5297

5297/10

LY 404187

Selective positive allosteric modulator of AMPA receptors

AMPA Receptor Modulators

10 mg (also 50 mg)

Small Molecules

98%

Store at +4°C

342.46

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LY 404187 is a selective AMPA receptor positive allosteric modulator (IC50 values are 0.15, 0.21, 1.66 and 5.65 M for GluA2i, GluA4i, GluA3i and GluA1i respectively). Potentiates glutamate and AMPA-evoked currents in prefrontal cortex (PFC) pyramidal neurons in vitro . Has no effect on NMDA- or kainate-evoked currents; also has no effect on K+ or Na+ ion channels. Potentiates PFC glutamatergic synaptic transmission in vitro and in vivo . Induces neurite growth in combination with ( S )-AMPA (Cat. No. 0254) in SH-SY5Y human neuroblastoma cells in vitro . Also reduces MPTP-induced toxicity in mice. Brain penetrant.

LY404187 selective ampa receptors positive allosteric modulators PAMs GLUA1 GLUA2 GLUA3 GLUA4 GLUR1 GLUR2 GLUR3 GLUR4 parkinson disease depression memory AMPA Receptors 5297,

Selective positive allosteric modulator of AMPA receptors

N-[2-(4 -Cyano[1,1 -biphenyl]-4-yl)propyl]-2-propanesulfonamide

C19H22N2O2S

C19H22N2O2S

211311-95-4

262

265 USD

Selective positive allosteric modulator of AMPA receptors