Cladribine | Tocris Bioscience 5292/10 product information

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product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Cladribine

catalog :

5292/10

quantity :

10 mg (also 50 mg)

price :

130 USD

citations: 1

Reference
Weiterer S, Kohlen T, Veit F, Sachs L, Uhle F, Lichtenstern C, et al. Galactomannan and Zymosan Block the Epinephrine-Induced Particle Transport in Tracheal Epithelium. PLoS ONE. 2015;10:e0143163 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

5292

SKU :

5292/10

product name :

Cladribine

description :

Deoxyadenosine analog; pro-apoptotic

target :

Apoptosis Inducer Compounds

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

99%

storage :

Store at +4°C

observed molecular weight :

285.69

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Cladribine is an adenosine deaminase (ADA)-resistant analog of deoxyadenosine. Exhibits anti-leukemic activity; Inhibits cell growth of lymphoid and myeloid neoplasm (IC50 = 20 - 87 nM). Pro-apoptotic; induces DNA double-strand breaks. Also inhibits ribonuclease reductase (IC50 = 0.11 - 0.28 M). Displays activity in vitro and in vivo . Orally bioavailable.

product keywords :

leukemia adenosine deaminase antileukemic proapoptotic ribonuclease reductase deoxyadenosine analogue analog 2-Chloro-2-deoxyadenosine antimetabolites 2-Chloro-2'-deoxyadenosine Apoptosis Inducers Ribonucleotide Reductase 5292,

extended description :

Deoxyadenosine analog; pro-apoptotic

chemical name text :

(2R,3S,5R)-5-(6-Amino-2-chloropurin-9-yl)-2-(hydroxymethyl)oxalan-3-ol

formula :

C10H12ClN5O3

formula text :

C10H12ClN5O3

cas num :

4291-63-8

USD :

128

USD 2025 :

130 USD

product details :

Deoxyadenosine analog; pro-apoptotic

alt names :

2-Chloro-2 -deoxyadenosine