SIS3 | Tocris Bioscience 5291 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

SIS3

catalog :

5291

quantity :

10 mg (also 50 mg)

price :

270 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Noskovičová N, Heinzelmann K, Burgstaller G, Behr J, Eickelberg O. Cub domain-containing protein 1 negatively regulates TGF-β signaling and myofibroblast differentiation. Am J Physiol Lung Cell Mol Physiol. 2018;314:L695-L707 pubmed publisher
Lin S, Sun L, Lyu X, Ai X, Du D, Su N, et al. Lactate-activated macrophages induced aerobic glycolysis and epithelial-mesenchymal transition in breast cancer by regulation of CCL5-CCR5 axis: a positive metabolic feedback loop. Oncotarget. 2017;8:110426-110443 pubmed publisher
Mou H, Vinarsky V, Tata P, Brazauskas K, Choi S, Crooke A, et al. Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal Cells. Cell Stem Cell. 2016;19:217-231 pubmed publisher
Echeverria C, Montorfano I, Sarmiento D, Becerra A, Nuñez Villena F, Figueroa X, et al. Lipopolysaccharide induces a fibrotic-like phenotype in endothelial cells. J Cell Mol Med. 2013;17:800-14 pubmed publisher

product information

brand :

Tocris

master code :

5291

SKU :

5291/10

product name :

SIS3

description :

Selective Smad3 inhibitor; inhibits TGF- R1 signaling

target :

Additional Transcription Factor Compounds

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

489.99

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Selective Smad3 inhibitor; attenuates TGF- 1-dependent Smad3 phosphorylation and DNA binding. Has no effect on Smad2, p38 MAPK, ERK or PI 3-kinase signaling. Inhibits TGF- 1-induced myofibroblast differentiation of dermal fibroblasts. Also inhibits TGF- 2-induced endothelial cell differentiation in iPSCs.

catalog number base :

5291

product keywords :

selective smad3 inhibitors inhibits TGF-beta1 TGF-B1 TGF- 1 receptors TGF-beta2 TGF-B2 TGF- 2 TGF-betaR1 TGF-BR1 TGF- R1 phosphorylation stem cells differentiation ipscs induced pluripotent Other Transcription Factors TGF-beta Receptors Other Differentiation Products 5291,

extended description :

Selective Smad3 inhibitor; inhibits TGF- R1 signaling

chemical name text :

1,2,3,4-Tetrahydro-6,7-dimethoxy-2-[(2E)-3-(1-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1-oxo-2-propenyl]-isoquinoline hydrochloride

formula :

C 28 H 27 N 3 O 3 .HCl

formula text :

C28H27N3O3.HCl

cas num :

521984-48-5

2020 USD :

259

2021 USD :

270 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage